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mention the fruit treatment of the bilious diarrhœa of the tropics, spoken of by the French physicians of Cochin China. Dr. Van der Burg of the Dutch Indies also strongly recommends the treatment of diarrhœa by fruits; in temperate regions using fruits like peaches, pears, etc., and in the tropics, lychies, mangosteens, etc. In regard to the mangosteens we must not forget that, while the bark is given because of the amount of tannin it contains, the composition of the pulp is very different. The fruit acids seem to exercise great influence in the cure of this obstinate disease and I do not hesitate to recommend for this purpose the camia and the ripe balimbin.

Botanical Description.—A tree much like the former. Leaves odd-pinnate. Leaflets, 3–4 pairs, obliquely ovate, acute, the terminal leaflet nearly lanceolate. Flowers on the trunk, branches and in the axils of the leaves. Fruit oblong, with 5 very prominent acute-angled ribs.

Habitat.—It grows, like the former plant, in all parts of the islands.

Rutaceæ.

Rue Family.

Ruta graveolens, L. (L. angustifolia, Pers.)

Nom. Vulg.—Rudu, Sp.; Rue, Eng.

Uses.—The rue of the European, American and Indian pharmacopœias is emmenagogue, antispasmodic, anthelmintic, excitant, diaphoretic, antiseptic and abortive. It contains an essential oil, and rutinic acid (C25H28O15, Borntrager), starch, gum, etc. The essential oil is greenish-yellow, thick, acrid and bitter; specific gravity 0.911. It boils at 228°, is slightly soluble in water, and soluble in absolute alcohol. It is promptly oxidized by nitric acid, and is converted into pelargonic acid and other fatty acids.

Rutin (or rutinic acid), according to Weiss, is a glucoside which exists in the form of fine needles, bright yellow in color. It is slightly soluble in cold water and more so in boiling water. It melts at 190°, and solidifies at freezing point, forming a resinous mass. Its physiological properties are as yet unknown. The part of the plant employed is the leaves, which owe their property, apparently, to the essential oil they contain, from which they also derive their strong and disagreeable odor and their bitter, acrid and nauseous taste.

It is used principally as a uterine stimulant or emmenagogue, for which purpose it is given in doses of 0.10–0.15 centigrams of the freshly powdered leaf and 0.05–0.10 centigrams of the fresh leaves infused in a liter of water. The dry powder of the leaf should not be used because the essential oil volatilizes and a large proportion of it is lost, which is the most active principle of the drug. It is an agent which should be prescribed with the greatest prudence for large doses are poisonous even to the point of causing death. The symptoms following such doses are colic, vomiting, bloody diarrhœa and tenesmus.

It is also used as an antihemorrhagic after childbirth, but its action is slow, not being felt for several hours after the administration of the drug; for this reason it cannot take the place of ergot, though it seems to be superior to the latter in passive hemorrhages. The essential oil is given internally in doses of 2–6 drops on a piece of sugar. It is sometimes used as an antispasmodic in hysteria, epilepsy and chorea.

The Chinese make extensive use of this drug and it is one of their principal abortives. In Hindostan the dried leaves are burnt and the smoke inhaled as a cure for catarrh in children. They are careful not to administer it to pregnant women.

Botanical Description.—A plant, 1 meter high, with leaves alternate, compound, the inferior ones 2–3-cleft; leaflets narrow, oblong, slightly fleshy. Flowers greenish-yellow, hermaphrodite, arranged in corymbose terminal cymes. Corolla, 4–5 free, concave petals. Calyx deeply divided, persistent. Stamens 8–10, free, in two whorls, inserted beneath a thick disc. Ovaries 5, unilocular, many-ovuled. Styles 5, first free, then united, forming a column terminating in a small stigma. Follicles 5, united at the base, 1 centimeter long, free superiorly, hard, rounded, rugose, opening on top. Seeds ovoid, angular, blackish, albuminous.

Habitat.—Common everywhere in the Philippines.

Xanthoxylum oxyphyllum, Edgew. (X. violaceum, Wall.; Fagara piperita, Blanco.)

Nom. Vulg.—Kayutana, Tag.; Salay, Saladay, Vis.

Uses.—The trunk bark is stimulant and is used as a sudorific in the treatment of fevers. The fresh bark is quite irritating, for which reason it is best to use bark taken from the more mature parts of the trunk, powdered and desiccated. The dose is 1/2–2 grams 2–3 times a day. Its stimulating properties render it useful in colic and in India it is used as a stomachic and digestive. Is seems also to possess diuretic properties.

Botanical Description.—A tree 30–35° high, with trunk thickly set with large spines. Leaves odd-pinnate. Leaflets ovate, acute, obtusely serrate, small transparent vesicles on the surface, spines on the midrib and common petiole. Calyx very small, monophyllous. Corolla twice as large as the calyx, 4 petals. Stamens 4, inserted on the receptacle, the same length as the petals. Ovary superior, 4-angled. No style. Stigmas 2.

Habitat.—Batangas, Morong, Manila.

Murraya exotica, L. (M. paniculata, Jack.; Connarus fœtens, and C. santaloides, Blanco.)

Nom. Vulg.—Kamunig̃, Tag.

Uses.—The leaves are stimulant and astringent, and are used in infusion (15 grams, to water one liter) to treat diarrhea and dysentery. The root and trunk barks are used for the same treatment and they as well as the leaves owe their properties to an essential oil and a bitter principle present in all parts of the plant. Vry has demonstrated the presence of a glucoside which he has named murrayin (C18H22O10); it crystallizes in small, white needles, is slightly bitter, soluble in hot water and alcohol, insoluble in ether, slightly soluble in cold water. It melts at 170°, and dissolves in alkaline solutions coloring them green. Boiled in dilute acids it splits into murrayetin and glucose. Murrayetin (C12H12O10) crystallizes in white needles, inodorous, tasteless, slightly soluble in cold water and in ether, soluble in hot water and alcohol. Heat destroys its green color in solutions; alkalies, in the presence of cold, increase it. The leaves and the bark of the plant contain an essential oil.

The foregoing description of this species applies equally well to the following species.

Botanical Description.—A small tree 12° high with leaves alternate, odd-pinnate. Leaflets lanceolate, almost entire, rigid with small dots on each surface. Flowers in axillary, very short, compound racemes. Calyx very small, monophyllous, 5 lanceolate lobules. Corolla much longer than the calyx, 5 lanceolate petals. Stamens 10, joined, but not entirely united at the base; 5 alternate stamens longer than the others. Anthers sessile, regular. Ovary superior, compressed and borne on a disc. Style 1, same length as the stamens. Stigma thick, depressed, apparently 4-angled. Fruit fleshy, ovoid, acute and somewhat curved at the end enclosing a seed with coriaceous, downy testa.

Murraya Koenigi, Spreng. (Bergera Koenigi, L.; Connarus sp., Blanco.)

Nom. Vulg.—(?)

Botanical Description.—Leaves alternate, odd-pinnate. Leaflets obliquely ovate, acute, entire and glabrous. The testa of the seed bears no down, and may be divided into two parts. The decoction of the leaves of this species as well as the former is used to allay toothache.

Citrus acida, F. (C. notissima, Blanco.)

Nom. Vulg.—Limón, Sp.; Dayap, Tag.; Lemon, Eng.

Uses.—The essence (essential oil) and juice of the fruit are the parts of the plant used in therapeutics. The essence extracted from the rind is yellow, fragrant, slightly bitter; density, 0.856; boiling point 165°. The juice which is turbid and pale yellow in color contains 9% citric acid, 3–5% gum and sugar and 2–8/10% inorganic salts. The essence is used to flavor certain pharmaceutical preparations, and is a diffusible stimulant which may be given internally in doses of 3–6 drops on a little sugar. The bitter rind is occasionally used in infusion as a stomachic and stimulant. The juice is most commonly used in lemonade, a cooling drink which, used intemperately in the Philippines, is apt to cause gastro-intestinal trouble, so commonly attributed to “irritation,” but really the result of a general atony of the digestive organs. Lemon juice is also used with very good results as a local cleansing application for sore throat, as well as externally on fetid ulcers. In some forms of malarial fever it seems to have given satisfactory results, administered internally.

In many navies lemon juice forms a part of the sea ration as a preventive of scurvy, upon which it exercises a real and noteworthy action. The Danish navy adopted it for this purpose in 1770, the English navy followed, then the French and possibly others. The English call it lime-juice, and its preventive dose is 30–40 grams a day. Its curative dose is 100–150 grams a day. To preserve the lime-juice it was bottled with a layer of oil, which, floating on the surface kept it from contact with the air; but this process gave it a bad taste as did also the addition of sulphate of calcium, and at present the English add, to each liter of juice, 60 grams of alcohol, which preserves it perfectly. Fonssagrives says that the antiscorbutic action of lemon juice is due rather to the vegetable juice itself than to the citric acid which it contains.

Botanical Description.—A most familiar tree 11° or more high, trunk with solitary thorns. Leaves ovate, obtuse, acute-toothed, the petiole bearing serrate wings. Calyx 4–6-toothed. Corolla, 4 thick petals. Filaments 10–25 on the receptacle, some joined and bearing 2–3 anthers. Fruit thin-skinned, globular, about 1′ in diameter; the rind adheres closely to the pulp.

(This fruit closely resembles, if it is not identical with the lime fruit, C. Limetta, or C. Bergamia, Risso, though Gray states that the leaf of the latter has a wingless petiole.—J. B. T.)

Habitat.—Common to all parts of the islands.

Citrus Bigaradia, Hook. f. (C. vulgaris, Risso; C. aurantium, Blanco.)

Nom. Vulg.—Naranjas del país, Sp.; Kahel, Kahil, Tag.; Native Orange, Eng.

Uses.—The rind of the cagel is the so-called bitter orange peel, the best of which comes from Curaçao and Barbadoes. It is tonic and is used in decoction and in syrup. The infusion of the leaves, 5–10 grams to the liter, is useful as a sedative and diaphoretic in hysterical and nervous attacks; the infusion of the flowers is similarly used. When distilled the flowers yield a very sweet essential oil called neroli, which is used as a perfume only.

Botanical Description.—A tree 15–20° high, trunk bearing solitary spines. Leaves medium lanceolate, serrate, the apex notched, petioles winged. Flowers usually solitary. Calyx 4–5-toothed. Corolla 4–5 petals. Filaments joined or separate. Anthers about 20. The fruit, a small orange 2′ or more in diameter, the peel closely adherent.

The C. aurantium verum or C. reticulata (Blanco) has a yellow pulp and the rind is readily separated from it, a thin net of fibers intervening.

Citrus decumana, L.

Nom. Vulg.—Suha, Lukban, Tag.; Toronjas Penins.; Naranjas, Sp.-Fil.

Uses.—The fruit, which is handsome and large, and the leaves and flowers, are used for the same purposes as those of C. bigaradia.

Habitat.—The above species are cultivated in all parts of the islands, and, like the variety C. aurantium verum, H. f. (C. reticulata, Blanco), commonly called naranjita, are among the most abundant of native fruits.

Ægle decandra, Naves. (Feronia ternata, Blanco.)

Nom. Vulg.—Malakabuyaw, Tag.; Tabog, Pam., Tag. (A species of Bael-Fruit Tree.)

Uses.—We do not know the medicinal use of this plant in the Philippines. Probably it has none, but we may give those of the species. R. marmelos, Cor., the fruit of which is almost identical with that of our species and is called Bela or Bael in India. The fruit of the Malakabuyaw is ovoid and full of a mucilaginous pulp, aromatic and acid, the same as that of the Bael. The uses of the latter are the following: The pulp acts as an astringent, but it would be more correctly called a tonic of the intestinal mucosa, for it has been experimentally proved that, although it checks diarrhœa, it also acts as a laxative in

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