A System of Logic: Ratiocinative and Inductive by John Stuart Mill (popular e readers .txt) 📕

as insulated truths of the lowest order of generalization; but it was reserved for Liebig, by an apt employment of the first two of our methods of experimental inquiry, to connect these truths together by a higher induction, pointing out what property, common to all these deleterious substances, is the really operating cause of their fatal effect.

When solutions of these substances are placed in sufficiently close contact with many animal products, albumen, milk, muscular fibre, and animal membranes, the acid or salt leaves the water in which it was dissolved, and enters into combination with the animal substance: which substance, after being thus acted upon, is found to have lost its tendency to spontaneous decomposition, or putrefaction.

Observation also shows, in cases where death has been produced by these poisons, that the parts of the body with which the poisonous substances have been brought into contact, do not afterwards putrefy.

And, finally, when the poison has been supplied in too small a quantity to destroy life, eschars are produced, that is, certain superficial portions of the tissues are destroyed, which are afterwards thrown off by the reparative process taking place in the healthy parts.

These three sets of instances admit of being treated according to the Method of Agreement. In all of them the metallic compounds are brought into contact with the substances which compose the human or animal body; and the instances do not seem to agree in any other circumstance. The remaining antecedents are as different, and even opposite, as they could possibly be made; for in some the animal substances exposed to the action of the poisons are in a state of life, in others only in a state of organization, in others not even in that. And what is the result which follows in all the cases? The conversion of the animal substance (by combination with the poison) into a chemical compound, held together by so powerful a force as to resist the subsequent action of the ordinary causes of decomposition. Now, organic life (the necessary condition of sensitive life) consisting in a continual state of decomposition and recomposition of the different organs and tissues; whatever incapacitates them for this decomposition destroys life. And thus the proximate cause of the death produced by this description of poisons, is ascertained, as far as the Method of Agreement can ascertain it.

Let us now bring our conclusion to the test of the Method of Difference. Setting out from the cases already mentioned, in which the antecedent is the presence of substances forming with the tissues a compound incapable of putrefaction, (and à fortiori incapable of the chemical actions which constitute life,) and the consequent is death, either of the whole organism, or of some portion of it; let us compare with these cases other cases, as much resembling them as possible, but in which that effect is not produced. And, first, "many insoluble basic salts of arsenious acid are known not to be poisonous. The substance called alkargen, discovered by Bunsen, which contains a very large quantity of arsenic, and approaches very closely in composition to the organic arsenious compounds found in the body, has not the slightest injurious action upon the organism." Now when these substances are brought into contact with the tissues in any way, they do not combine with them; they do not arrest their progress to decomposition. As far, therefore, as these instances go, it appears that when the effect is absent, it is by reason of the absence of that antecedent which we had already good ground for considering as the proximate cause.

But the rigorous conditions of the Method of Difference are not yet satisfied; for we cannot be sure that these unpoisonous bodies agree with the poisonous substances in every property, except the particular one, of entering into a difficultly decomposable compound with the animal tissues. To render the method strictly applicable, we need an instance, not of a different substance, but of one of the very same substances, in circumstances which would prevent it from forming, with the tissues, the sort of compound in question; and then, if death does not follow, our case is made out. Now such instances are afforded by the antidotes to these poisons. For example, in case of poisoning by arsenious acid, if hydrated peroxide of iron is administered, the destructive agency is instantly checked. Now this peroxide is known to combine with the acid, and form a compound, which, being insoluble, cannot act at all on animal tissues. So, again, sugar is a well-known antidote to poisoning by salts of copper; and sugar reduces those salts either into metallic copper, or into the red suboxide, neither of which enters into combination with animal matter. The disease called painter's colic, so common in manufactories of white lead, is unknown where the workmen are accustomed to take, as a preservative, sulphuric acid lemonade (a solution of sugar rendered acid by sulphuric acid). Now diluted sulphuric acid has the property of decomposing all compounds of lead with organic matter, or of preventing them from being formed.

There is another class of instances, of the nature required by the Method of Difference, which seem at first sight to conflict with the theory. Soluble salts of silver, such for instance as the nitrate, have the same stiffening antiseptic effect on decomposing animal substances as corrosive sublimate and the most deadly metallic poisons; and when applied to the external parts of the body, the nitrate is a powerful caustic; depriving those parts of all active vitality, and causing them to be thrown off by the neighbouring living structures, in the form of an eschar. The nitrate and the other salts of silver ought, then, it would seem, if the theory be correct, to be poisonous; yet they may be administered internally with perfect impunity. From this apparent exception arises the strongest confirmation which the theory has yet received. Nitrate of silver, in spite of its chemical properties, does not poison when introduced into the stomach; but in the stomach, as in all animal liquids, there is common salt; and in the stomach there is also free muriatic acid. These substances operate as natural antidotes, combining with the nitrate, and if its quantity is not too great, immediately converting it into chloride of silver; a substance very slightly soluble, and therefore incapable of combining with the tissues, although to the extent of its solubility it has a medicinal influence, though an entirely different class of organic actions.

The preceding instances have afforded an induction of a high order of conclusiveness, illustrative of the two simplest of our four methods; though not rising to the maximum of certainty which the Method of Difference, in its most perfect exemplification, is capable of affording. For (let us not forget) the positive instance and the negative one which the rigour of that method requires, ought to differ only in the presence or absence of one single circumstance. Now, in the preceding argument, they differ in the presence or absence not of a single circumstance, but of a single substance: and as every substance has innumerable properties, there is no knowing what number of real differences are involved in what is nominally and apparently only one difference. It is conceivable that the antidote, the peroxide of iron for example, may counteract the poison through some other of its properties than that of forming an insoluble compound with it; and if so, the theory would fall to the ground, so far as it is supported by that instance. This source of uncertainty, which is a serious hindrance to all extensive generalizations in chemistry, is however reduced in the present case to almost the lowest degree possible, when we find that not only one substance, but many substances, possess the capacity of acting as antidotes to metallic poisons, and that all these agree in the property of forming insoluble compounds with the poisons, while they cannot be ascertained to agree in any other property whatsoever. We have thus, in favour of the theory, all the evidence which can be obtained by what we termed the Indirect Method of Difference, or the Joint Method of Agreement and Difference; the evidence of which, though it never can amount to that of the Method of Difference properly so called, may approach indefinitely near to it.

§ 2. Let the object be[34] to ascertain the law of what is termed induced electricity; to find under what conditions any electrified body, whether positively or negatively electrified, gives rise to a contrary electric state in some other body adjacent to it.

The most familiar exemplification of the phenomenon to be investigated is the following. Around the prime conductors of an electrical machine, the atmosphere to some distance, or any conducting surface suspended in that atmosphere, is found to be in an electric condition opposite to that of the prime conductor itself. Near and around the positive prime conductor there is negative electricity, and near and around the negative prime conductor there is positive electricity. When pith balls are brought near to either of the conductors, they become electrified with the opposite electricity to it; either receiving a share from the already electrified atmosphere by conduction, or acted upon by the direct inductive influence of the conductor itself: they are then attracted by the conductor to which they are in opposition; or, if withdrawn in their electrified state, they will be attracted by any other oppositely charged body. In like manner the hand, if brought near enough to the conductor, receives or gives an electric discharge; now we have no evidence that a charged conductor can be suddenly discharged unless by the approach of a body oppositely electrified. In the case, therefore, of the electric machine, it appears that the accumulation of electricity in an insulated conductor is always accompanied by the excitement of the contrary electricity in the surrounding atmosphere, and in every conductor placed near the former conductor. It does not seem possible, in this case, to produce one electricity by itself.

Let us now examine all the other instances which we can obtain, resembling this instance in the given consequent, namely, the evolution of an opposite electricity in the neighbourhood of an electrified body. As one remarkable instance we have the Leyden jar; and after the splendid experiments of Faraday in complete and final establishment of the substantial identity of magnetism and electricity, we may cite the magnet, both the natural and the electro-magnet, in neither of which it is possible to produce one kind of electricity by itself, or to charge one pole without charging an opposite pole with the contrary electricity at the same time. We cannot have a magnet with one pole: if we break a natural loadstone into a thousand pieces, each piece will have its two oppositely electrified poles complete within itself. In the voltaic circuit, again, we cannot have one current without its opposite. In the ordinary electric machine, the glass cylinder or plate, and the rubber, acquire opposite electricities.

From all these instances, treated by the Method of Agreement, a general law appears to result. The instances embrace all the known modes in which a body can become charged with electricity; and in all of them there is found, as a concomitant or consequent, the excitement of the opposite electric state in some other body or bodies. It seems to follow that the two facts are invariably connected, and that the excitement of electricity in any body has for one of its necessary conditions the possibility of a simultaneous excitement of the opposite electricity in some neighbouring body.

As the two contrary electricities can only be produced together, so they can only cease together. This may be shown by an application of the Method of Difference to the example of the Leyden jar. It needs scarcely