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of different molecular pressures.

SPORE FORMATION—A mode of reproduction in lower forms of life by which resistant bodies, spores, are formed. These have many analogies with the seed of higher plants.

SYMBIOSIS—A mutual adaptation between parasite and host.

TRANSUDATION—The normal interchange of fluid between the blood and the tissue fluids. The material interchanged is the transudate.

TROPISM—The influence of forces which direct the movement of cells.

ULTRA-MICROSCOPE—A form of microscope which by means of oblique illumination renders visible objects so small as to be invisible with the ordinary microscope.

VIRUS—A substance either living or formed by living things which may cause disease.

Index

Amoeba, 13

Anthrax, 109

Antitoxin, 154


Bacteria, 116

      adaptation in, 123

      Ă¦robic, 122

      anærobic, 122

      artificial cultivation of, 119

      distribution in nature, 121

      growth and reproduction, 118

      mode of action in disease, 144

      size, 117

      spore formation, 118

      substances affecting growth of, 123

      toxin production by, 144

      variations in, 123

Blood, 35

      circulation of, 33, 80

      vessels, 32

Body, 22

      defenses of, 146

      organs of, 28

      reserve force of, 50

      surfaces of, 22

Brain, 31


Cerebro-spinal meningitis, 188

Chemotropism, 93

Cretinism, 37


Darwinism, 240

Death, 57

      decomposition after, 51

      rigor after, 60

      signs of, 59

Disease, 1

      action of poisons, 44

      acute and chronic, 219

      industrialism as factor in, 243

      lesions of, 46

      superstitions concerning, 10

      urban life as factor in, 244

      wealth and poverty as factors in, 246

Ductless glands, 37


Embryo, 77

Epilepsy, 209

Eugenics, 215


Foetus, 32

      infection of, 200

Foot and Mouth Disease, 129


Glands, 22

Growth, 62


Heart, 33, 221

      disease of, 223

Heliotropism, 93

Heredity, 197

      influence of alcohol, 206

      of insanity, 209

      variations and imitations, 204

Hookworm disease, 179


Immunity, 148

      theories of, 149

      natural, 150

Infection, 135

      from external surface, 136

      from genito-urinary surface, 137

      from lungs, 138

      from mouth, 138

      from stomach and intestines, 139

      from wounds, 141

      in children, 195

      in wild animals, 191

      latent, 166

      mixed, 160

      racial susceptibility to, 191

      resistance to, 143

      by air, 170

      by insects, 171

Infectious diseases, 97

      carriers of, 185

      comparison with fermentation, 108

      epidemics of, 98

      endemic, epidemic and sporadic forms, 188

      modes of transmission, 161

Inflammation, 80

acute and chronic, 95

Injury, 54-74

Insanity, 231

      causes of, 232

      question of increase, 235


Lesion, 17

Leucocytes, 36

      migration of, 92

Living matter, 10


Malaria, 175

      rĂ´le of mosquito in transmitting, 178

Malformations, 211

      heredity of, 215

Maternal impressions, 212


Nervous system, 228

      disease of, 230

      effect of social life on, 233

Neurasthenia, 238


Old age, 51

      atrophy in, 51

      blood vessels in, 54

      causes of death in, 56

      in animals and plants, 55

      mental activity in, 53

Osmosis, 91

Opsonius, 153

Ovum, 201

      fertilization of, 198

      infection of, 199


Phagocytosis, 86

Plague, 182

      transmission by animals, 183

Plasmodium Malariae, 175

Preventive medicine, 242

Protozoa, 124

      distribution in nature, 125

      mode of growth, 125

      sexual differentiation, 125

      spore formation, 125

Polyomyelitis, 190


Repair, 46

      conditions influencing, 47


Scar, 49

Skin, 21

Sleeping sickness, 173

Smallpox, 187

Spontaneous generation, 106

Sunburn, 83

Syphilis, 193


Tetanus, 142

Thymus, 52

Thyroid, 37

Tonsils, 52

Toxins, 144

Tropisms, 93

Trypanosomes, 172

Tuberculosis, 163

infection by sputum, 169

modes of extension, 163

Tumors, 64

      benign and malignant, 69

      cells of, 66

      color, size and shape, 65

      growth of, 65

      importance of, 77

      origin of, 66

      question of increase, 69

      theories of cause, 71

      treatment of, 77

Typhoid fever, 170


Ultra-microscopic organisms, 128


Virus, 128


Yellow fever, 178

Notes 1.

They do, however, take place, since within comparatively few years whole species have completely disappeared; for example, the great auk and the passenger pigeon. In these cases it is not known what part disease played in the destruction.

2.

A tissue represents an aggregate of similar cells with the intercellular substances in relation with these as connective tissue, muscular tissue, etc. Where such cell aggregates are localized and where the cells are arranged in structures having definite form and size and performing a definite function, it is customary to designate such structures as organs, as the brain, liver, etc.

3.

By cachexia is understood a condition of malnutrition and emaciation which is usually accompanied by a pale sallow color of the skin.

4.

By trauma is understood a wound or injury of any sort.

5.

The term exudation is used to designate the passing of cells and fluid from the vessels in inflammation; the material is the exudate.

6.

By transudation is meant the constant interchange between the blood and the tissue fluid.

7.

The interesting analogy between fermentation and infectious disease did not escape attention. A clear fluid containing in solution sugar and other constituents necessary for the life of the yeast cells will remain clear provided all living things within it have been destroyed and those in the air prevented from entering. If it be inoculated with a minute fragment of yeast culture containing a few yeast cells, for a time no change takes place; but gradually the fluid becomes cloudy, bubbles of gas appear in it and its taste changes. Finally it again becomes clear, a sediment forms at the bottom, and on re-inoculating it with yeast culture no fermentation takes place. The analogy is obvious, the fluid in the first instance corresponds with an individual susceptible to the disease, the inoculated yeast to the contagion from a case of transmissible disease, the fermentation to the illness with fever, etc., which constitutes the disease, the returning clearness of the fluid to the recovery, and like the fermenting fluid the individual is not susceptible to a new attack of the disease. It will be observed that during the process both the yeast and the material which produced the disease have enormously increased. Fermentation of immense quantities of fluid could be produced by the sediment of yeast cells at the bottom of the vessel and a single case of smallpox would be capable of infecting multitudes.

8.

Flexner has recently succeeded in isolating and cultivating the organism of poliomyelitis, but the organism is so small that its classification is not possible.

9.

The comparison here is with the atrium of a Pompeiian house.

10.

This was the case of a woman, by occupation a cook, whose numerous exchanges of service were accompanied by the appearance of cases of typhoid fever in the families. This became so marked that an examination was made and she was found to be a typhoid carrier and as such constantly discharging typhoid bacilli. She is now isolated.

11.

By structure as used in this wide sense, there must be understood not merely the anatomical structure, which is revealed by the dissecting knife and microscope, but molecular structure, or the manner in which elements are arranged to form the molecule, as well.

 

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